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Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
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Peripheral arterial disease: a literature review
P Abdulhannan1, D A Russell, S Homer-Vanniasinkam
1Leeds Vascular Institute, Leeds General Infirmary, Leeds, UK. peshang81@yahoo.co.uk
British Medical Bulletin
|October 20, 2012
Summary
Aggressive risk factor modification is crucial for reducing cardiovascular mortality in peripheral arterial disease (PAD) patients. Endovascular treatments are rapidly advancing, with gene therapy and tissue engineering showing future promise.
Area of Science:
- Vascular Medicine
- Cardiovascular Research
- Regenerative Medicine
Background:
- Peripheral arterial disease (PAD) significantly impacts patient quality of life and life expectancy.
- PAD is associated with an elevated risk of cardiovascular events.
Purpose of the Study:
- To review current management strategies, investigations, and risk factors for peripheral arterial disease.
- To explore emerging treatments and future research directions in PAD.
Main Methods:
- Comprehensive literature search of major databases (PubMed, MEDLINE, Cochrane Library, Google Scholar) up to February 2012.
- Keywords included 'peripheral arterial disease' combined with terms related to management, investigations, risk factors, epidemiology, and treatments.
- Studies were limited to those published in the English language.
Main Results:
- Aggressive modification of risk factors is essential for reducing cardiovascular mortality in PAD patients.
- The optimal choice between endovascular and surgical interventions for PAD remains a subject of ongoing debate.
- Endovascular technologies are rapidly evolving to enhance treatment effectiveness.
Conclusions:
- Future treatments for PAD may include gene therapy and therapeutic angiogenesis.
- Tissue engineering offers potential for developing novel grafts for PAD.
- Further research into atherosclerosis pathophysiology is needed to identify new pharmacotherapeutic targets.
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