Dual-energy perfusion CT of non-diseased lung segments using dual-source CT: correlation with perfusion SPECT
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Updated: May 17, 2026

Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment
Published on: August 9, 2024
Yoshie Kunihiro1, Munemasa Okada, Naofumi Matsunaga
1Department of Radiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. kyoshie@yamaguchi-u.ac.jp
Purpose:
To determine the utility of dual-energy perfusion CT (DEpCT) of non-diseased lung segments, using dual-source CT, in comparison with perfusion single-photon emission computed tomography (SPECT).
Materials And Methods:
28 patients (18 male and 10 female; mean age 63 years; age range 18-86 years) underwent DEpCT and SPECT within a 3-day interval. The presence and location of perfusion defects in each segment of the lungs were evaluated.
Results:
Perfusion defects were noted in 7 of 361 segments (1.9%) by DEpCT and in 19 of 361 segments (5.3%) by perfusion SPECT. DEpCT was in good agreement with perfusion SPECT for 338 of 361 segments (93.6%). Intraobserver agreement was also good, ranging from 93.4 to 93.6% (κ = 0.64-0.75, p < 0.01).
Conclusion:
For non-diseased lung segments, DEpCT correlated well with SPECT.
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