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[Studies on transient hyperphosphatasemia].

T Hoshino1, M Sasaki, H Watanabe

  • 1Department of Clinical Pathology, Nihon University School of Medicine, Tokyo.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|January 1, 1990
PubMed
Summary

Transient hyperphosphatasemia (TH) affects children, with elevated alkaline phosphatase (ALP) levels normalizing within a month. Sugar chain aberrations of ALP are the likely cause, not viral infections.

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Area of Science:

  • Pediatrics
  • Clinical Chemistry

Background:

  • Transient hyperphosphatasemia (TH) is a rare condition characterized by temporary elevations in serum alkaline phosphatase (ALP).
  • Understanding the incidence and characteristics of TH is crucial for accurate diagnosis and management in pediatric populations.

Purpose of the Study:

  • To investigate the incidence, clinical features, and laboratory findings of transient hyperphosphatasemia in young children.
  • To explore potential causes and diagnostic markers for TH.

Main Methods:

  • Retrospective analysis of 36 cases of TH identified from 8 primary medical institutions over 2.5 years.
  • Clinical data, including age, symptoms, and ALP levels, were collected and analyzed.
  • Follow-up ALP levels and isoenzyme patterns were examined in a subset of cases.

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Main Results:

  • TH was identified in 36 children aged 8-92 months (average 25.4 months).
  • Elevated ALP levels, sometimes exceeding 100 K.A. units, normalized within one month in most cases.
  • While fever, diarrhea, and respiratory infections were common, no specific underlying cause was identified; sugar chain aberrations of ALP are suspected.

Conclusions:

  • Transient hyperphosphatasemia is a benign condition in children that resolves spontaneously.
  • Characteristic ALP isoenzyme patterns may persist for up to three months despite normalization of ALP levels.
  • The exact mechanism remains unknown, but non-viral factors like sugar chain aberrations are implicated.