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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

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Lemierre syndrome.

Ai Lee Lim¹, Kin Choo Pua

¹Department of Otorhinolarngology, Hospital Pulau Pinang, Jalan Residensi, 10990 Penang. quenstanylim@hotmail.com

The Medical Journal of Malaysia

|October 23, 2012

Summary

Lemierre syndrome, a rare but serious oropharyngeal infection, involves septic thrombophlebitis of the internal jugular vein. Prompt diagnosis and treatment are crucial for managing this potentially fatal condition.

Area of Science:

Infectious Diseases
Microbiology
Vascular Surgery

Background:

Lemierre syndrome, a rare condition, originates from acute bacterial oropharyngeal infections.
Historically known as "the forgotten fever," it was first described in 1900.
Fusobacterium necrophorum is the most common causative agent.

Observation:

The syndrome involves secondary septic thrombophlebitis of the internal jugular vein.
Embolization to the lungs and other organs can occur.
Diagnosis is often incidental, relying on unexpected culture results.

Findings:

Lemierre syndrome, though uncommon, remains a serious and potentially fatal illness.
It was particularly dangerous in the pre-antibiotic era.

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Modern diagnosis often relies on identifying Fusobacterium necrophorum in blood cultures.

Implications:

Increased awareness and prompt diagnosis are vital for effective management.
Early recognition can prevent severe complications and mortality.
This case highlights the importance of considering Lemierre syndrome in oropharyngeal infections.