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Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
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The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
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In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...

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Gene doping: gene delivery for olympic victory.

David Gould1

  • 1Barts & The London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK. d.j.gould@qmul.ac.uk

British Journal of Clinical Pharmacology
|October 23, 2012
PubMed
Summary

Gene therapy advancements may soon enable gene doping in sports. Developing effective detection and prevention strategies is crucial to maintain fair play in athletic competitions.

Keywords:
detectiongene dopinggene therapysecreted proteinssporttranscription factors

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Area of Science:

  • Biomedical science
  • Sports medicine
  • Molecular biology

Background:

  • Gene therapy is advancing, with treatments proving effective in clinical trials.
  • The success of gene therapy raises concerns about its potential misuse in sports, termed 'gene doping'.
  • Existing gene delivery technologies are effective.

Purpose of the Study:

  • To provide an overview of successful gene therapy clinical trials.
  • To highlight potential targets for gene doping.
  • To emphasize the need for detection and prevention plans.

Main Methods:

  • Review of successful gene therapy clinical trials.
  • Identification of potential gene doping targets.
  • Analysis of detection challenges based on gene product location.

Main Results:

  • Gene therapy technologies are effective and transferable to sports.
  • Potential gene doping targets have been identified.
  • Detection methods will depend on whether the gene product is secreted or retained.

Conclusions:

  • Gene doping is a feasible threat due to current gene therapy advancements.
  • Effective gene delivery technologies necessitate proactive detection and prevention strategies.
  • Monitoring and combating gene doping is essential for sports integrity.