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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Asthma I: Introduction01:28

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Chronic Inflammation

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Related Experiment Video

Updated: May 17, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Recurrent polymyositis triggered by bronchiectasis-associated infections.

Bon D Ku1, Hyun Young Shin

  • 1Department of Neurology, Kwandong University College of Medicine, Myongjig Hospital, Goyang, Gyeong Gi, Korea. neurodasan@paran.com

International Journal of Rheumatic Diseases
|October 23, 2012
PubMed
Summary

Recurrent polymyositis can be triggered by systemic infections, suggesting a non-specific autoimmune response. This case highlights infections associated with bronchiectasis as a potential trigger for this rare condition.

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Last Updated: May 17, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

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Published on: June 17, 2025

Area of Science:

  • Immunology
  • Autoimmune Diseases
  • Infectious Diseases

Background:

  • Polymyositis is a rare autoimmune disorder characterized by cell-mediated inflammation of muscles.
  • Systemic infections are known potential triggers for polymyositis, but recurrent cases are infrequently reported.
  • Understanding triggers is crucial for managing autoimmune conditions.

Observation:

  • A 69-year-old woman presented with recurrent episodes of polymyositis.
  • Her recurrent episodes were consistently associated with infections linked to bronchiectasis.
  • This clinical presentation is unusual, given the rarity of recurrent polymyositis triggered by infections.

Findings:

  • The patient's recurrent polymyositis was demonstrably triggered by bronchiectasis-associated infections.
  • This case suggests that polymyositis may involve a non-specific autoimmune antigenic response to systemic infections.
  • The findings point towards a potential mechanism linking infection and autoimmune muscle inflammation.

Implications:

  • Recurrent polymyositis triggered by systemic infections may indicate a broader autoimmune susceptibility.
  • Identifying specific infectious triggers could lead to targeted prevention or treatment strategies for polymyositis.
  • This case broadens the understanding of polymyositis pathogenesis and its relationship with infectious triggers.