Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptional transactivation turns human iPSC-derived macrophages into an adenovirus-producing cell state.

Journal of virology·2026
Same author

Clicking viruses-with chemistry toward mechanisms in infection.

Journal of virology·2025
Same author

Activated blood-derived human primary T cells support replication of HAdV C5 and virus transmission to polarized human primary epithelial cells.

Journal of virology·2025
Same author

FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases.

Cellular and molecular life sciences : CMLS·2024
Same author

Selective autophagy impedes KSHV entry after recruiting the membrane damage sensor galectin-8 to virus-containing endosomes.

Cell reports·2024
Same author

Metagenomic study of lake microbial mats reveals protease-inhibiting antiviral peptides from a core microbiome member.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same journal

Malaria Cytoskeletal Proteins Require Alveolin-Alveolin Interactions for Differential Localization: Recruitment and Organization of Alveolin Proteins.

Cellular microbiology·2025
Same journal

Vam6/Vps39/TRAP1-domain proteins influence vacuolar morphology, iron acquisition and virulence in Cryptococcus neoformans.

Cellular microbiology·2021
Same journal

Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane.

Cellular microbiology·2021
Same journal

Chlamydia and HPV induce centrosome amplification in the host cell through additive mechanisms.

Cellular microbiology·2021
Same journal

Entry of the Varicellovirus Canid herpesvirus 1 into Madin-Darby canine kidney epithelial cells is pH-independent and occurs via a macropinocytosis-like mechanism but without increase in fluid uptake.

Cellular microbiology·2021
Same journal

Dengue virus replication enhances labile zinc pools by modulation of ZIP8.

Cellular microbiology·2021
See all related articles

Related Experiment Video

Updated: May 17, 2026

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

Adenovirus signalling in entry.

Nina Wolfrum1, Urs F Greber

  • 1Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

Cellular Microbiology
|October 23, 2012
PubMed
Summary
This summary is machine-generated.

Viruses manipulate host cell signaling through forward and reverse pathways. Human adenoviruses utilize cell receptors for forward signals and cellular machinery for reverse signals to control infection outcomes.

More Related Videos

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

Measuring Attachment and Internalization of Influenza A Virus in A549 Cells by Flow Cytometry
07:25

Measuring Attachment and Internalization of Influenza A Virus in A549 Cells by Flow Cytometry

Published on: November 4, 2015

Related Experiment Videos

Last Updated: May 17, 2026

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

Measuring Attachment and Internalization of Influenza A Virus in A549 Cells by Flow Cytometry
07:25

Measuring Attachment and Internalization of Influenza A Virus in A549 Cells by Flow Cytometry

Published on: November 4, 2015

Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • Viruses interact with host cells, triggering cellular signaling pathways.
  • These signaling events, termed forward and reverse signals, influence infection progression and viral fate.
  • Human adenoviruses are significant pathogens with complex interactions within host cells.

Purpose of the Study:

  • To elucidate the mechanisms of forward and reverse signaling in human adenovirus infections.
  • To understand how adenoviruses utilize host cell receptors and intracellular machinery.
  • To explore the impact of these signals on viral lifecycle and infection outcome.

Main Methods:

  • Analysis of virus-host cell interactions.
  • Investigation of cell surface receptor engagement by adenoviruses.
  • Study of intracellular transport mechanisms, including acto-myosin and kinesin motors.
  • Examination of viral genome uncoating processes.

Main Results:

  • Human adenoviruses activate host cell growth, intracellular transport, and innate immune responses via forward signaling through cell surface receptors.
  • Adenoviruses employ acto-myosin, integrins, and kinesin motors for reverse signaling, facilitating stepwise genome uncoating.
  • Both forward and reverse signaling pathways significantly impact the course and outcome of adenovirus infections.

Conclusions:

  • Viral signaling is a critical determinant of infection dynamics.
  • Human adenoviruses strategically manipulate host cell signaling for replication and propagation.
  • Understanding these signaling mechanisms offers potential targets for antiviral strategies.