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Concentration decrease of corticosteroid binding globulin (CBG) in plasma of the mare throughout pregnancy.

B Martin1, P Silberzahn

  • 1Physiologie de la Reproduction, UA CNRS 555, Université P. et M. Curie, Paris, France.

Journal of Steroid Biochemistry
|January 1, 1990
PubMed
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Plasma corticosteroid-binding globulin (CBG) binding capacity significantly decreases in mares during pregnancy. This reduction is linked to lower CBG levels, unlike most mammals but similar to rhesus monkeys.

Area of Science:

  • Reproductive biology
  • Endocrinology
  • Biochemistry

Background:

  • Corticosteroid-binding globulin (CBG) plays a crucial role in regulating glucocorticoid bioavailability.
  • Changes in CBG levels during pregnancy are known in some species but not extensively studied in equids.

Purpose of the Study:

  • To investigate the changes in CBG binding capacity and concentration in pregnant mares.
  • To compare these changes with those observed in other mammalian species.

Main Methods:

  • Equilibrium dialysis and gel equilibration were used to measure CBG binding capacity.
  • Immunoelectrophoresis was employed to determine blood CBG concentration.

Main Results:

  • A significant decrease in plasma CBG binding capacity was observed in mares throughout pregnancy.

Related Experiment Videos

  • This decline in binding capacity correlated with a reduction in blood CBG concentration.
  • The observed pattern in mares differs from most mammals, with the exception of the rhesus monkey.

    • Conclusions:

    • Pregnancy in mares is associated with a unique decline in CBG binding capacity and concentration.
    • This finding highlights species-specific adaptations in corticosteroid transport during gestation.
    • Further research is warranted to understand the physiological implications of these changes in mares.