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Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

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Flexible direct-growth CNT biosensors.

Yun-Tzu Chang¹, Jing-Huei Huang, Meng-Che Tu

¹National Tsing Hua University, Department of Materials Science and Engineering, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan.

Biosensors & Bioelectronics

|October 23, 2012

Summary

A novel flexible biosensor using carbon nanotubes (CNTs) was developed for detecting human serum albumin (HSA). This wearable sensor shows high sensitivity, paving the way for advanced in vivo diagnostics.

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Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Flexible electronics are crucial for wearable and implantable devices.
Carbon nanotubes (CNTs) offer unique electrical properties for biosensing applications.
Developing biocompatible sensors is essential for in vivo monitoring.

Purpose of the Study:

To fabricate a low-temperature, flexible biosensor using CNTs on a polyimide substrate.
To enhance the biosensor's biocompatibility for in vivo applications.
To demonstrate the sensor's capability in detecting human serum albumin (HSA).

Main Methods:

Growing CNTs on a flexible polyimide substrate at low temperatures.
Coating with biocompatible parylene for insulation.
Surface modification of CNTs using UV-ozone, EDC, and NHS for protein conjugation.
Utilizing anti-HSA for specific capture and BSA for blocking non-specific sites.
Quantifying HSA detection via electrochemical impedance spectroscopy.

Main Results:

Successful fabrication of a flexible CNT biosensor.
Demonstrated quantitative detection of human serum albumin (HSA).
Achieved a low detection limit of approximately 3×10⁻¹¹ mg/ml for HSA.
Validated sensor performance using electrochemical impedance spectroscopy.

Conclusions:

The developed flexible CNT biosensor is feasible for detecting HSA.
The sensor exhibits high sensitivity and biocompatibility.
The technology holds significant potential for wearable biosensors and implantable diagnostics.