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Related Experiment Videos

Age differences on ileal glucose absorption in rats.

M P Vinardell1

  • 1Departament de Ciencies Fisiologiques Humanes i de la Nutricio, Facultat de Farmacia, Universitat de Barcelona, Spain.

Mechanisms of Ageing and Development
|February 15, 1990
PubMed
Summary

Aging reduces D-glucose absorption in rat ileum. Active transport and diffusion slow down with age, impacting overall sugar uptake significantly.

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Area of Science:

  • Gastroenterology
  • Physiology
  • Aging Research

Background:

  • Intestinal absorption of nutrients like D-glucose is crucial for energy metabolism.
  • Understanding age-related changes in nutrient absorption is vital for geriatric health.

Purpose of the Study:

  • To investigate the impact of aging on D-glucose absorption in the rat ileum.
  • To quantify changes in active transport and diffusion rates with age.

Main Methods:

  • In vivo perfusion technique in fasted young (21-day-old) and old (18-month-old) rats.
  • D-glucose concentrations ranging from 2.5 to 40 mmol/l were used.
  • Phloridzin was employed to inhibit active transport and assess its contribution.

Main Results:

  • Aging led to a reduction in total D-glucose absorption, active transport rate, and diffusion coefficient.
  • Saturation of D-glucose absorption occurred at 10 mmol/l in both age groups.
  • Phloridzin inhibited active transport by 65-70% at 40 mmol/l D-glucose.

Conclusions:

  • Aging significantly impairs D-glucose absorption in the rat ileum.
  • Both active transport and passive diffusion mechanisms are affected by aging.
  • These findings highlight age-related declines in intestinal absorptive capacity.

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