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Updated: May 17, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Non-celiac gluten sensitivity.

Knut E A Lundin1, Armin Alaedini

  • 1Department of Gastroenterology, Oslo University Hospital Rikshospitalet, Center for Immune Regulation, University of Oslo, Oslo, Norway. k.e.a.lundin@medisin.uio.no

Gastrointestinal Endoscopy Clinics of North America
|October 23, 2012
PubMed
Summary

Non-celiac gluten sensitivity (NCGS) describes individuals with gluten-related symptoms but no celiac disease or wheat allergy. Research is ongoing to confirm gluten as the sole trigger for NCGS symptoms.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Nutrition Science

Background:

  • Gluten sensitivity is often associated with celiac disease and wheat allergy.
  • Some individuals experience symptoms after gluten ingestion without evidence of these conditions.

Purpose of the Study:

  • To review current information on non-celiac gluten sensitivity (NCGS).
  • To explore the symptomatology, epidemiology, genetics, serology, histology, and pathophysiology of NCGS.

Main Methods:

  • Literature review of existing studies on NCGS.
  • Analysis of in vitro and in vivo experimental data.
  • Examination of serologic and histologic findings.

Main Results:

  • NCGS presents with symptoms unrelated to celiac disease or wheat allergy.
  • The exact role of gluten as the sole trigger in NCGS requires further investigation.
  • Available data covers various aspects of NCGS, including its presentation and potential mechanisms.

Conclusions:

  • Non-celiac gluten sensitivity is a recognized condition distinct from celiac disease and wheat allergy.
  • Further research is needed to establish gluten as the definitive cause of NCGS symptoms.
  • Understanding the pathophysiology of NCGS is crucial for accurate diagnosis and management.