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Acute blood glucose fluctuations can decrease blood glutathione and adiponectin levels in patients with type 2
Chia-Jen Tsai1, Ching-Jung Hsieh, Shih-Chen Tung
1Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City, Taiwan.
Diabetes Research and Clinical Practice
|October 23, 2012
Summary
Acute blood glucose fluctuations significantly impact glutathione and adiponectin levels in type 2 diabetes patients. Lower levels of these antioxidants are associated with greater glycemic variability.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Oxidative Stress Research
Background:
- Glutathione, an antioxidant, combats hyperglycemia-induced oxidative stress.
- Adiponectin helps manage metabolic disturbances in type 2 diabetes mellitus (DM).
Purpose of the Study:
- To investigate the relationship between blood glucose fluctuations and blood levels of glutathione and adiponectin in type 2 DM patients.
Main Methods:
- 34 type 2 DM patients were studied.
- Short-term glycemic variability assessed using mean amplitude of glycemic excursions (MAGE) over 72 hours via continuous glucose monitor system (CGMS).
- Long-term glycemic variability assessed by standard deviation (SD) of HbA1c over 2 years. Glutathione and adiponectin levels measured post-CGMS.
Main Results:
- Glutathione levels negatively correlated with MAGE (r = -0.543; P < 0.001).
- Adiponectin levels negatively correlated with MAGE and SD of HbA1c (r = -0.64 and r = -0.55; P < 0.001).
- MAGE independently predicted serum adiponectin and glutathione levels (P = 0.002 and P = 0.004, respectively).
Conclusions:
- Significant associations exist between acute blood glucose variability, glutathione, and adiponectin in type 2 diabetic patients on oral hypoglycemic agents.
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