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Published on: February 3, 2012
[Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome in a patient with chronic hepatitis B infection]
Óscar Núñez Martínez1, Isabel Marquina Ibáñez, Elena Ruiz Bravo-Burguillos
1Unidad de Digestivo, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España. onumar@gmail.com
Abstract:
We describe the case of a female patient with a previous diagnosis of primary biliary cirrhosis (PBC) and chronic hepatitis B in inactive phase who developed increased transaminase levels with no evidence of hepatitis B virus reactivation while receiving ursodeoxycholic acid treatment. A liver biopsy showed changes compatible with overlapping autoimmune hepatitis (AIH). Budesonide treatment achieved normalization of transaminase levels. We provide a review of PBC and AIH overlap syndrome and discuss the particular features of this case that led us to this diagnosis, as well as the treatment provided.
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