Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

Laminins are the Adhesive Proteins of Basal Lamina

Laminins are the Adhesive Proteins of Basal Lamina

Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...

Anchoring Junctions

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...

Cancer Cell Migration through Invadopodia

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...

Types of Membrane Protrusions

Types of Membrane Protrusions

The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections with a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optic neuritis following COVID-19 vaccination: Case series and review of the literature.

Journal francais d'ophtalmologie·2024

Same author

Retinal arterial occlusion and patent foramen ovale: A case study-based review.

Journal francais d'ophtalmologie·2023

Same author

[Anisocoria secondary to a primary ciliary cyst].

Journal francais d'ophtalmologie·2023

Same author

Intravitreal fasudil monotherapy for treatment of refractory diabetic macular edema: A prospective interventional case series.

Journal francais d'ophtalmologie·2023

Same author

The additive effect of intravitreal dexamethasone combined with bevacizumab in refractory diabetic macular edema.

Journal francais d'ophtalmologie·2023

Same author

[Ethambutol-induced toxic optic neuropathy during treatment of tuberculosis meningitis in a child].

Journal francais d'ophtalmologie·2023

Same journal

When the brain never fully registers surgery and postoperative inflammation is controlled: a two-phase model of postoperative pain.

Orthopaedics & traumatology, surgery & research : OTSR·2026

Same journal

Arthroscopic anatomic reconstruction of the ATFL and CFL using allograft: Return to sport and one-year functional outcomes in chronic ankle instability.

Orthopaedics & traumatology, surgery & research : OTSR·2026

Same journal

Survival and Recurrence of Infection After Revision of Infected Total Elbow Arthroplasty: A French Multicenter Study (2013-2023) of 137 infected Total Elbow Arthroplasties.

Orthopaedics & traumatology, surgery & research : OTSR·2026

Same journal

Tibiotalocalcaneal arthrodesis using a retrograde intramedullary nail and augmented allograft after failed total ankle replacement: an exploratory retrospective matched cohort study.

Orthopaedics & traumatology, surgery & research : OTSR·2026

Same journal

Comparison between arithmetic, osteoarthritic and prosthetic HKA: a cohort of computer assisted unrestricted kinematically aligned TKA patients.

Orthopaedics & traumatology, surgery & research : OTSR·2026

Same journal

MRI assessment of muscle damage in total hip arthroplasty via SuperPATH approach.

Orthopaedics & traumatology, surgery & research : OTSR·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 17, 2026

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells

Published on: February 18, 2016

Ewing-like adamantinoma.

M M Hamdane¹, L Charfi, M Driss

¹Histopathology Department, Salah Azaiez Institute, Bab Saâdoun, 1006 Tunis, Tunisia. hamdanemoncef@yahoo.fr

Orthopaedics & Traumatology, Surgery & Research : OTSR

|October 23, 2012

Summary

This summary is machine-generated.

This case highlights the diagnostic challenges of Ewing-like adamantinoma, a rare bone tumor. Initial misdiagnosis as Ewing

More Related Videos

A Minimally Invasive Lesion Technique for Muscles Intrinsic to the Odontophore of Aplysia californica

A Minimally Invasive Lesion Technique for Muscles Intrinsic to the Odontophore of Aplysia californica

Published on: August 16, 2019

Related Experiment Videos

Last Updated: May 17, 2026

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells

Published on: February 18, 2016

A Minimally Invasive Lesion Technique for Muscles Intrinsic to the Odontophore of Aplysia californica

A Minimally Invasive Lesion Technique for Muscles Intrinsic to the Odontophore of Aplysia californica

Published on: August 16, 2019

Area of Science:

Oncology
Pathology
Orthopedic Surgery

Background:

Adamantinoma is a rare primary bone tumor with a low-grade malignant potential.
Ewing-like adamantinoma is an uncommon variant that poses diagnostic challenges.
Accurate diagnosis is crucial for appropriate treatment and patient management.

Observation:

A 20-year-old male presented with a 2-year history of left leg swelling.
Initial imaging revealed an intracortical, osteolytic tibial tumor with soft tissue invasion.
Histopathology initially suggested Ewing's sarcoma based on small round cells expressing CD99.

Findings:

A subsequent biopsy after tumor progression revealed osteofibrous and epithelial components.
The recurrent tumor expressed pancytokeratin and vimentin but was negative for CD99.
This led to a revised diagnosis of Ewing-like adamantinoma.

Implications:

This case underscores the importance of considering Ewing-like adamantinoma in the differential diagnosis of tibial tumors.
Immunohistochemical markers, particularly CD99 negativity, are critical for distinguishing it from Ewing's sarcoma.
Delayed or incorrect diagnosis can impact treatment strategies and patient outcomes.