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Updated: May 17, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Targeting the androgen receptor

Terence W Friedlander1, Charles J Ryan

  • 1Division of Genitourinary Medical Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA. terence.friedlander@ucsf.edu

The Urologic Clinics of North America
|October 23, 2012
PubMed

Insights

Prostate cancer relies on androgen receptor (AR) signaling. New therapies target persistent AR signaling and resistance mechanisms in castration-resistant prostate cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Endocrinology

Background:

  • Androgen receptor (AR) signaling is crucial for prostate cancer growth and survival.
  • Medical castration and antiandrogen therapies reduce AR activity but often lead to castration resistance.
  • Understanding AR's evolution under hormonal therapy is key to overcoming resistance.

Purpose of the Study:

  • To review mechanisms of persistent AR signaling in the castrate environment.
  • To highlight emerging and clinical-stage therapies for castration-resistant prostate cancer.

Main Methods:

  • Literature review of molecular mechanisms of AR signaling in prostate cancer.
  • Analysis of current and investigational therapeutic strategies targeting AR.

Main Results:

  • Novel mechanisms of castration-resistant prostate cancer progression driven by AR have been identified.
  • New drug targets for AR signaling have emerged from structural and evolutionary studies.
  • Androgen synthesis inhibitors and direct AR inhibitors show promise.

Conclusions:

  • Persistent AR signaling is a key driver of castration-resistant prostate cancer.
  • Novel therapeutic agents targeting AR are advancing treatment options.
  • Further research into AR mechanisms will yield more effective therapies.

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