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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The Tumor Microenvironment

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The Extrinsic Apoptotic Pathway

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Related Experiment Video

Updated: May 17, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

Tumor necrosis factor.

Wen-Ming Chu1

  • 1Cancer Biology Program, University of Hawaii Cancer Center, 651 Ilalo Street, Honolulu, HI 96813, USA. wchu@cc.hawaii.edu

Cancer Letters
|October 23, 2012
PubMed
Summary

Tumor necrosis factor (TNF) is a key cytokine involved in health and disease. This review covers TNF signaling, focusing on molecular mechanisms and outcomes like inflammation, cell death, and survival.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Tumor necrosis factor (TNF) is a vital cytokine with diverse physiological and pathological roles.
  • Understanding TNF's molecular mechanisms is crucial for addressing inflammatory diseases and cancer.

Purpose of the Study:

  • To review the history, family members, and functions of TNF.
  • To highlight recent findings on TNF-induced signaling pathways (NF-κB, AP-1, MLKL).
  • To summarize advances in TNF-mediated cell survival, apoptosis, and necroptosis.

Main Methods:

  • Literature review of TNF signaling.
  • Focus on molecular mechanisms of pathway activation.
  • Synthesis of recent research on TNF-induced cellular responses.

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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Related Experiment Videos

Last Updated: May 17, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Main Results:

  • TNF activates NF-κB and AP-1 pathways, crucial for pro-inflammatory cytokine expression.
  • TNF triggers the MLKL cascade, leading to reactive oxygen species (ROS) generation.
  • Recent insights into TNF's role in cell survival, apoptosis, and necroptosis.

Conclusions:

  • Continued research into TNF signaling mechanisms is essential for understanding immune disorders and cancer-related inflammation.
  • Emerging concepts in TNF biology offer potential therapeutic targets.