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Modelling Delta-Notch perturbations during zebrafish somitogenesis.

Philip J Murray¹, Philip K Maini, Ruth E Baker

¹Centre for Mathematical Biology, Mathematical Institute, 24-29 St. Giles', Oxford OX1 3LB, UK. murrayp@maths.ox.ac.uk

Developmental Biology

|October 23, 2012

Summary

A new model explains zebrafish somitogenesis by showing how coupled molecular oscillators create a wavefront, controlling somite formation. This model clarifies variations in somite size and gene expression patterns in mutants.

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Area of Science:

Developmental biology
Systems biology
Molecular genetics

Background:

The 'clock and wavefront' model explains vertebrate somitogenesis, with a wavefront setting somite position and a clock controlling periodicity.
Recent gene expression data in zebrafish mutants provide opportunities for quantitative evaluation of this model.

Purpose of the Study:

To evaluate the 'clock and wavefront' hypothesis using a new model based on oscillator coupling and emergent wavefront propagation.
To provide mechanistic explanations for observed phenomena in zebrafish somitogenesis mutants.

Main Methods:

Quantitative analysis of spatiotemporal gene expression patterns in zebrafish embryos.
Modeling oscillator coupling driving emergent wavefront propagation.

Main Results:

The proposed model explains variations in somite measurements across zebrafish mutants.
It accounts for delayed somitogenesis and 'salt and pepper' gene expression patterns upon disruption of oscillator coupling.
The model also explains spatial correlations in 'salt and pepper' patterns observed in Delta-Notch mutants.

Conclusions:

Oscillator coupling is crucial for emergent wavefront propagation in somitogenesis.
The model offers testable predictions for further experimental validation.
This work advances our understanding of the quantitative mechanisms underlying somitogenesis.