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Cutl1: a potential target for cancer therapy
Kuan-can Liu1, Bao-shun Lin, Meng Zhao
1Institute for Laboratory Medicine, Fuzhou General Hospital, PLA, Fuzhou, Fujian 350025, PR China.
Cellular Signalling
|October 23, 2012
Summary
CDP (Cutl1) regulates gene expression and influences development and cancer. This review highlights its role in tumor progression, suggesting down-regulating Cut1 as a potential cancer therapy.
Area of Science:
- Molecular Biology
- Genetics
- Cancer Research
Background:
- CDP, encoded by the Cutl1 gene, is a transcription regulator influencing gene expression via DNA-binding.
- CDP activity is modulated by various modifications (transcriptional, posttranscriptional, translational, posttranslational).
Purpose of the Study:
- To systematically analyze the role of CDP in normal development and tumor progression.
- To emphasize CDP's interactors and downstream molecules.
- To evaluate Cut1 as a therapeutic target in cancer.
Main Methods:
- Literature review of studies on CDP/Cutl1.
- Analysis of CDP's involvement in normal development.
- Examination of CDP's role in tumor progression, including its interactors and downstream targets.
Main Results:
- CDP plays a dual role in gene expression, acting as both a repressor and promoter.
- CDP is implicated in both normal development and the progression of various cancers.
- Specific interactors and downstream molecules of CDP involved in cancer were identified.
Conclusions:
- Cut1 (CDP) promotes cancer progression.
- Down-regulating Cut1 expression presents a promising therapeutic strategy for cancer treatment.
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