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Published on: February 9, 2017
Structural characterization of titanium-doped Bioglass using isotopic substitution neutron diffraction
Richard A Martin1, Robert M Moss, Nilay J Lakhkar
1School of Physical Sciences, Ingram Building, University of Kent, Canterbury, CT2 7NH, UK. R.A.Martin@Aston.ac.uk
Physical Chemistry Chemical Physics : PCCP
|October 23, 2012
Summary
Adding titanium dioxide to Bioglass® enhances bone regeneration. This study reveals titanium
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Solid State Chemistry
Background:
- 45S5 Bioglass® promotes bone regeneration and dental remineralization.
- Titanium dioxide addition may enhance the bioactivity of silicate glasses.
Purpose of the Study:
- Investigate the structural effects of incorporating 4 mol% titanium dioxide into Bioglass®.
- Determine the coordination and network connectivity changes upon TiO2 addition.
Main Methods:
- Isotopic substitution neutron diffraction.
- X-ray Absorption Near Edge Structure (XANES) spectroscopy.
- Solid-state magic angle spinning (MAS) Nuclear Magnetic Resonance (NMR) spectroscopy.
Main Results:
- Titanium atoms are primarily surrounded by 5.2(1) oxygen atoms.
- Network connectivity decreases from 2.11 to 1.97 with TiO2 addition.
- Titanium incorporation is homogenous on the micron scale and does not disrupt intermediate-range order.
Conclusions:
- Titanium dioxide incorporation into Bioglass® alters network connectivity.
- The study provides the first isotopic substitution data for melt-quenched Bioglass derivatives.
- Results confirm titanium's structural role and homogenous distribution within the glass matrix.
