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Related Concept Videos

Glial Cells01:04

Glial Cells

Overview
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: May 17, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

Neural progenitor cells regulate microglia functions and activity.

Kira I Mosher1, Robert H Andres, Takeshi Fukuhara

  • 1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.

Nature Neuroscience
|October 23, 2012
PubMed
Summary
This summary is machine-generated.

Mouse neural progenitor cells (NPCs) possess a unique secretory profile that influences microglial activity. These neural precursor cells regulate microglial functions, demonstrating a bidirectional communication within the brain.

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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

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Related Experiment Videos

Last Updated: May 17, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Area of Science:

  • Neuroscience
  • Cell Biology
  • Immunology

Background:

  • Microglia play crucial roles in brain development and disease.
  • Neural progenitor cells (NPCs) are critical for neurogenesis.
  • The interaction between NPCs and microglia is not fully understood.

Purpose of the Study:

  • To investigate the secretory profile of mouse NPCs.
  • To determine the effect of NPCs on microglial function.
  • To elucidate the role of NPC-derived factors in modulating microglia.

Main Methods:

  • Analysis of the secretory proteome of mouse NPCs.
  • Co-culture experiments with NPCs and primary microglia.
  • Assessment of microglial activation, proliferation, and phagocytosis.
  • In vivo studies using mouse models to evaluate the effects of NPC-derived factors.

Main Results:

  • NPCs exhibit a distinct secretory protein profile compared to other brain cells.
  • NPCs modulate microglial activation, proliferation, and phagocytosis.
  • NPC-derived vascular endothelial growth factor (VEGF) is essential for some of these modulatory effects.
  • NPCs regulate microglial functions in vivo.

Conclusions:

  • NPCs possess unique secretory capabilities that influence microglial behavior.
  • There is a bidirectional communication pathway between NPCs and microglia.
  • NPCs can actively regulate microglial functions, impacting brain homeostasis and potentially neurodevelopmental processes.