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The CD46-Jagged1 interaction is critical for human TH1 immunity

Gaëlle Le Friec1, Devon Sheppard, Pat Whiteman

  • 1Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Guy's Hospital, London, UK.

Nature Immunology
|October 23, 2012
PubMed
Summary

The immune system uses CD46 to regulate T helper type 1 (T(H)1) cells. This study reveals CD46 interacts with Jagged1, a Notch ligand, crucial for T(H)1 cell function and preventing infections.

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