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Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
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Structural stabilization of DNA-templated nanostructures: crosslinking with 2,5-bis(2-thienyl)pyrrole monomers
1Georgia Institute of Technology, Atlanta, Georgia, USA.
Organic & Biomolecular Chemistry
|October 23, 2012
Abstract:
Ordered 2,5-bis(2-thienyl)pyrrole (SNS) zipper arrays are formed by hybridization of complementary DNA oligomers each containing covalently bound SNS monomers. Upon oxidation with HRP/H(2)O(2), these SNS arrays are converted to oligomers having specific lengths and conformation. As a consequence of this reaction the two SNS-containing strands are permanently crosslinked.
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