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A validated biomarker panel to identify peripheral artery disease.
William R Hiatt1, Armen Zakharyan, Eric T Fung
1University of Colorado School of Medicine, Division of Cardiology, Aurora, CO 80045, USA. Will.Hiatt@UCDenver.edu
Vascular Medicine (London, England)
|October 23, 2012
Summary
A novel biomarker panel shows promise for identifying peripheral artery disease (PAD) in at-risk individuals. This panel, combined with clinical data, can help detect PAD more effectively than clinical assessment alone.
Area of Science:
- Biomarkers and Diagnostics
- Vascular Medicine
- Primary Care Research
Background:
- Current peripheral artery disease (PAD) screening relies on the ankle-brachial index (ABI).
- Previous research linked specific biomarkers (β(2)-microglobulin, cystatin C, high-sensitivity C-reactive protein, glucose) to PAD.
- A need exists for improved PAD detection in at-risk populations.
Purpose of the Study:
- To evaluate a biomarker panel combined with clinical parameters for predicting PAD.
- To assess the diagnostic performance of this combined model in a primary care setting.
Main Methods:
- 1025 at-risk subjects (smokers/diabetics ≥50 years, or ≥70 years) were enrolled.
- Subjects underwent clinical assessment, blood draw for biomarkers, and ABI measurement.
- Logistic regression analyzed biomarker performance, with PAD defined as ABI < 0.90.
Main Results:
- Among 979 evaluable subjects, 8.5% had PAD (n=83).
- The combined model achieved a C-statistic of 0.73 (95% CI 0.67-0.79).
- The model identified 17 of 20 PAD patients missed by clinical assessment alone, performing well even in those without prior PAD history.
Conclusions:
- A biomarker panel integrated with clinical assessment shows potential for enhancing PAD detection.
- This approach may improve identification of PAD in individuals at risk.
- Further validation could support the use of this panel in clinical practice.
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