Jove
Visualize
Contact Us

Related Concept Videos

Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
Two-Dimensional Microscopy in Microbiology01:29

Two-Dimensional Microscopy in Microbiology

Two-dimensional (2D) microscopy encompasses a range of optical techniques that capture images within a single focal plane, offering detailed representations of microscopic structures. These techniques are essential in biological and medical research, enabling the visualization of cellular and subcellular structures with different levels of contrast and specificity.There are several major types of 2D microscopy, each with strengths and applications.Bright-Field MicroscopyBright-field microscopy...
Overview of Microscopy Techniques01:22

Overview of Microscopy Techniques

The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting mitochondrial protease in diffuse gliomas.

Molecular cancer therapeutics·2026
Same author

Alterations in chromatin organization promote totipotent-like features in a DPPA2/DUX-dependent manner.

The EMBO journal·2026
Same author

FUS and TAF15 safeguard the critical functions of the ribonucleoprotein network formed by EWSR1 and newly synthesized RNA.

bioRxiv : the preprint server for biology·2026
Same author

Heparin-Binding Proteins in the Nanoparticle Corona Enhance Cellular Uptake through Glycocalyx Interactions.

ACS nano·2025
Same author

High-Pressure Freezing EM Tomography of Entire Ribbon Synapses in the Retina.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Pericyte-tumor crosstalk facilitates metastatic tumor cell latency through PIEZO1-activated lysophospholipid transfer.

bioRxiv : the preprint server for biology·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 17, 2026

Nano-fEM: Protein Localization Using Photo-activated Localization Microscopy and Electron Microscopy
13:13

Nano-fEM: Protein Localization Using Photo-activated Localization Microscopy and Electron Microscopy

Published on: December 3, 2012

Introduction: nanoimaging techniques in biology.

Alioscka A Sousa1, Michael J Kruhlak

  • 1National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA. sousaali@mail.nih.gov

Methods in Molecular Biology (Clifton, N.J.)
|October 23, 2012
PubMed
Summary

This volume explores advanced nanoimaging techniques crucial for visualizing cellular machinery. It covers light, electron, and scanning probe microscopy for detailed molecular biology insights.

More Related Videos

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
07:13

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

Related Experiment Videos

Last Updated: May 17, 2026

Nano-fEM: Protein Localization Using Photo-activated Localization Microscopy and Electron Microscopy
13:13

Nano-fEM: Protein Localization Using Photo-activated Localization Microscopy and Electron Microscopy

Published on: December 3, 2012

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
07:13

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

Area of Science:

  • Cellular biology
  • Biophysics
  • Microscopy

Background:

  • Cellular machinery complexity requires advanced visualization tools.
  • Existing imaging methods have limitations in nanoscale resolution.
  • Understanding molecular biology necessitates high-resolution imaging.

Purpose of the Study:

  • To present a comprehensive overview of nanoimaging techniques.
  • To detail specialized methods in light, electron, and scanning probe microscopy.
  • To explore combinatorial and complementary imaging approaches.

Main Methods:

  • Focus on techniques achieving nanoscale spatial resolutions.
  • Discussion of light microscopy advancements.
  • Exploration of electron microscopy and scanning probe microscopy applications.

Main Results:

  • Provides a structured compilation of cutting-edge nanoimaging methodologies.
  • Highlights diverse techniques for visualizing molecular components.
  • Emphasizes the integration of multiple imaging approaches.

Conclusions:

  • Nanoimaging is essential for dissecting cellular complexity.
  • The volume offers a valuable resource for researchers in molecular biology and biophysics.
  • Advanced microscopy techniques are key to future biological discoveries.