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Updated: May 17, 2026
14:32
Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
Published on: February 27, 2016
From sirtuin biology to human diseases: an update
Carlos Sebastián1, F Kyle Satterstrom, Marcia C Haigis
1Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA.
The Journal of Biological Chemistry
|October 23, 2012
Summary
Sirtuins, NAD(+)-dependent enzymes, regulate aging and metabolism. This review updates their protective roles in age-related diseases like cancer and neurodegeneration.
Area of Science:
- Biochemistry
- Molecular Biology
- Gerontology
Background:
- Sirtuins are NAD(+)-dependent enzymes.
- Initially recognized for aging regulation.
- Increasingly linked to diverse biological processes.
Purpose of the Study:
- To review the known roles of mammalian sirtuins.
- Focus on roles in aging, metabolism, and age-related diseases.
Main Methods:
- Literature review of sirtuin functions.
- Focus on seven mammalian sirtuins.
Main Results:
- Sirtuins regulate aging and metabolic homeostasis.
- They offer protective functions against cancer, neurodegeneration, and cardiovascular disease.
Conclusions:
- Mammalian sirtuins have multifaceted roles.
- Understanding sirtuins is crucial for addressing age-related conditions.
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