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Identification of circulating microRNAs as biomarkers in cancers: what have we got?

Yu Sun1, Kuo Zhang, Gaowei Fan

  • 1Beijing Hospital ofthe Ministry of Health, Beijing, People's Republic of China.

Clinical Chemistry and Laboratory Medicine
|October 23, 2012
PubMed

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...