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The ITS2 Database
16:17

The ITS2 Database

Published on: March 12, 2012

IUPHAR-DB: updated database content and new features.

Joanna L Sharman1, Helen E Benson, Adam J Pawson

  • 1University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.

Nucleic Acids Research
|October 23, 2012
PubMed
Summary
This summary is machine-generated.

The IUPHAR database now includes detailed information on 366 endogenous peptide ligands, enhancing its utility for researchers studying drug targets and bioactive molecules. This update improves understanding of peptide ligand interactions and their clinical relevance.

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Area of Science:

  • Pharmacology
  • Biochemistry
  • Bioinformatics

Background:

  • The International Union of Basic and Clinical Pharmacology (IUPHAR) database is a key resource for drug target and ligand information.
  • Previous releases focused on G protein-coupled receptors, nuclear hormone receptors, and ion channels, along with small molecule ligands.
  • The database provides expert-driven annotations from primary literature.

Purpose of the Study:

  • To update the IUPHAR database with comprehensive information on endogenous peptide ligands.
  • To enhance the annotation of bioactive molecules and their interactions with drug targets.
  • To improve the clinical relevance and inter-database linking of pharmacological data.

Main Methods:

  • Annotation of 366 endogenous peptide ligands, including amino acid sequences and post-translational modifications.
  • Matching drug targets with their endogenous ligands (peptides and small molecules).
  • Curating data on peptide ligands derived from precursor proteins and their modifications.
  • Expanding information on clinical relevance and inter-database links.
  • Initiating a pilot project for enzyme curation as drug targets.

Main Results:

  • Detailed annotation of 366 endogenous peptide ligands, including sequences, precursor gene links, and species differences.
  • Identification of bioactive peptide ligands generated by post-translational modification.
  • Enhanced data on the clinical relevance of targets and ligands.
  • Increased number of linked external databases.
  • Pilot curation of enzymes as drug targets initiated.

Conclusions:

  • The updated IUPHAR database offers richer insights into endogenous peptide ligands and their roles.
  • Enhanced data facilitates a deeper understanding of drug target interactions and clinical applications.
  • The database continues to expand its scope to include enzymes, further supporting pharmacological research.