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FOXM1 coming of age: time for translation into clinical benefits?

Muy-Teck Teh1

  • 1Centre for Clinical and Diagnostic Oral Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London London, UK.

Frontiers in Oncology
|October 23, 2012
PubMed

Insights

Forkhead Box M1 (FOXM1) is a key cancer driver found in most human tumors. Understanding its role could lead to new biomarkers for cancer risk, screening, and personalized therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The transcription factor Forkhead Box M1 (FOXM1) has been implicated in human tumorigenesis for over a decade.
  • Aberrant upregulation of FOXM1 is observed in a vast majority of human cancers, suggesting a fundamental role in cancer development.
  • FOXM1 expression levels correlate with tumor progression, from initiation to metastatic invasion.

Purpose of the Study:

  • To review and discuss the oncogenic mechanisms of FOXM1.
  • To explore the potential clinical applications of FOXM1 knowledge.
  • To highlight FOXM1's role in chemotherapeutic drug resistance.

Main Methods:

  • Literature review of studies on FOXM1 in human tumorigenesis.
  • Analysis of FOXM1's role in various cancer types and stages.
  • Discussion of FOXM1's link to drug resistance.

Main Results:

  • FOXM1 plays a significant oncogenic role across numerous cancer types.
  • FOXM1 expression is dose-dependent and linked to tumor progression and metastasis.
  • FOXM1 is causally linked to resistance to chemotherapeutic drugs.

Conclusions:

  • Despite its established roles in oncogenesis, FOXM1's clinical benefits are yet to be realized.
  • Exploiting knowledge of FOXM1's mechanisms can aid in clinical applications.
  • FOXM1 holds potential as a biomarker for risk prediction, early screening, diagnostics, and personalized cancer therapy.
Keywords:
FOXM1cancer biomarkerscancer stem cellsepigenetic markerspersonalised medicine

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