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[Neurological disorders in pregnancy].

Gordana Brozović¹, Ivan Sklebar, Branka Mazul Sunko

¹University Department of Anaesthesiology, Resuscitation and Intensive Care Medicine, Sveti Duh University Hospital, Zagreb, Croatia. gbrozovic@kbsd.hr

Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti

|October 24, 2012

Summary

Preeclampsia, a condition marked by high blood pressure in pregnancy, can cause severe neurologic issues. Magnesium may help prevent seizures and protect the brain in preeclamptic patients.

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Published on: November 20, 2015

Area of Science:

Obstetrics and Gynecology
Neurology
Nephrology

Context:

Preeclampsia is a serious pregnancy complication characterized by hypertension, edema, and proteinuria.
Neurologic complications in severe preeclampsia mimic hypertensive encephalopathy.
Recognizing and treating these neurologic symptoms is crucial for maternal and fetal health.

Purpose:

To highlight the neurologic manifestations of severe preeclampsia.
To emphasize the role of endothelial cell dysfunction in multiorgan failure.
To discuss the therapeutic potential of magnesium in managing preeclampsia-related neurologic complications.

Summary:

Severe preeclampsia presents with neurologic symptoms including headache, vomiting, mental disorders, visual disturbances, sensorimotor deficits, and seizures.
Endothelial cell dysfunction is identified as the primary driver of multiorgan failure in preeclampsia.
Magnesium levels are decreased in severe preeclampsia with cerebral edema; magnesium supplementation shows promise in reducing seizures by lowering neuronal excitability and protecting the endothelium.

Impact:

Improved recognition and management of severe preeclampsia's neurologic complications.
Potential for enhanced therapeutic strategies utilizing magnesium to mitigate seizure risk.
Further research into endothelial dysfunction and magnesium's neuroprotective effects in preeclampsia.