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Microbial metabolism studies of the antimalarial drug arteether
I S Lee1, H N ElSohly, C D Hufford
1Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.
Pharmaceutical Research
|February 1, 1990
Abstract:
Microbial metabolism studies of the antimalarial drug arteether (1) have shown that arteether is metabolized by a number of microorganisms. Large-scale fermentation with Aspergillus niger (ATCC 10549) and Nocardia corallina (ATCC 19070) have resulted in the isolation of four microbial metabolites which have been characterized using two-dimensional nuclear magnetic resonance (2D-NMR) techniques. These metabolites have been identified as "AEM1" (2), 3 alpha-hydroxydeoxyarteether (3), 3 alpha-hydroxydeoxydihydroartemisinin (4), and deoxydihydroartemisinin (5).