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Updated: May 17, 2026

Dithranol as a Matrix for Matrix Assisted Laser Desorption/Ionization Imaging on a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
Published on: November 26, 2013
Matrix-assisted laser desorption ionization/time-of-flight mass spectrometry for clinical diagnosis
Yi-Tzu Cho1, Hung Su, Tiao-Lai Huang
1Department of Cosmetic Applications and Management, Yuh-Ing Junior College of Health Care & Management, Kaohsiung, Taiwan.
Background:
Matrix-assisted laser desorption ionization/time-of-flight (MALDI-TOF) mass spectrometry is known as an extremely sensitive analytical tool for characterizing different types of biological compounds including proteins, peptides and lipids. Since MALDI-TOF analysis requires very simple sample pretreatment, the technique can be used for rapidly detecting biochemical compounds serving as disease biomarkers.
Results:
This mini-review focuses on the applications of MALDI-TOF in the detection of potential disease biomarkers in various biological samples.
Conclusions:
The potential disease biomarkers are mostly abundant proteins, peptides, or lipids including: albumin; hemoglobin; α-defensins; trimethylamine; phospholipids; and glycated α- and β-globin, which are indicators of albuminuria; fecal occult blood and ischemic stroke; dry eye disease and/or aging; trimethylaniuria; breast cancer; and diabetes, respectively.
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07:49Matrix-assisted Laser Desorption/Ionization Time of Flight (MALDI-TOF) Mass Spectrometric Analysis of Intact Proteins Larger than 100 kDa
Published on: September 9, 2013
10:47Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization (IR-MALDESI)
Published on: March 24, 2016
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