Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cannabinoid receptor localization in brain.

M Herkenham1, A B Lynn, M D Little

  • 1Unit on Functional Neuroanatomy, National Institute of Mental Health, Bethesda, MD 20892.

Proceedings of the National Academy of Sciences of the United States of America
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated touch screen device for recording complex rodent behaviors.

Journal of neuroscience methods·2014
Same author

Wistar rats acquire and maintain self-administration of 20 % ethanol without water deprivation, saccharin/sucrose fading, or extended access training.

Psychopharmacology·2014
Same author

Opioid activation of toll-like receptor 4 contributes to drug reinforcement.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2012
Same author

The neuropharmacology of prolactin secretion elicited by 3,4-methylenedioxymethamphetamine ("ecstasy"): a concurrent microdialysis and plasma analysis study.

Hormones and behavior·2011
Same author

Interaction of 5-HT2A and 5-HT2C receptors in R(-)-2,5-dimethoxy-4-iodoamphetamine-elicited head twitch behavior in mice.

The Journal of pharmacology and experimental therapeutics·2010
Same author

Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity.

Neuroscience·2010
Same journal

The TaMYB55-TaSnRK1α1-TabZIP9 module confers heat stress tolerance in wheat.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Superstatistics approach to turbulent circulation fluctuations.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

A molecular timescale for evolution of cobamide biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Pierre Chambon, a pioneer of molecular biology and gene regulation in eukaryotes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Granulosa cell glycogen fuels the avascular corpus luteum.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Researchers characterized cannabinoid receptors using a potent synthetic cannabinoid, [3H]CP 55,940. This receptor

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Cannabinoids exert effects through specific receptors.
  • Understanding cannabinoid receptor distribution is crucial for pharmacology.

Purpose of the Study:

  • To characterize and localize cannabinoid receptors in mammalian brain sections.
  • To confirm the identity of the characterized receptor with known cannabinoid effects.

Main Methods:

  • Used radiolabeled synthetic cannabinoid [3H]CP 55,940 for binding assays.
  • Employed autoradiography to map receptor distribution in brain tissue.
  • Competed binding with various natural and synthetic cannabinoids.

Main Results:

  • [3H]CP 55,940 binding potencies correlated with biological effects of cannabinoids.

Related Experiment Videos

  • Cannabinoid receptor distribution is conserved across mammalian species.
  • Highest binding densities observed in basal ganglia, hippocampus, and cerebellum.

    • Conclusions:

    • The characterized receptor likely mediates behavioral and pharmacological effects of cannabinoids.
    • Cannabinoid receptor distribution suggests roles in cognition, movement, and potentially explains low toxicity of delta 9-tetrahydrocannabinol at high doses.