Related Experiment Video
Updated: May 17, 2026
09:51
Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
Published on: March 3, 2020
Hot-melt coating with lipid excipients
Vincent Jannin1, Yvonne Cuppok
1Gattefossé S.A.S., 36 chemin de Genas - BP 603, 69804 Saint-Priest, France.
International Journal of Pharmaceutics
|October 24, 2012
Summary
Lipid excipients offer a solvent-free alternative for coating particles, enabling rapid application and modified drug release. Understanding lipid properties is key for effective drug delivery applications.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Traditional polymer coatings require solvents and gliding agents for drug particle processing.
- These processes can be time-consuming and limit the coating of high surface area particles.
Purpose of the Study:
- To explore lipid excipients as an alternative to conventional polymer coatings for pharmaceutical applications.
- To highlight the advantages of lipid-based coatings, including solvent-free application and rapid processing.
Main Methods:
- Melting of lipid excipients for direct application onto substrate particles.
- Evaluation of physico-chemical properties of various lipid excipients.
- Assessment of the impact of lipid excipients on drug release profiles.
Main Results:
- Lipid excipients can be applied directly by melting, eliminating the need for solvents.
- This solvent-free method allows for rapid coating, even on powders with high specific surface areas.
- Different lipid excipients exhibit varying properties that influence drug release.
Conclusions:
- Lipid excipients provide an efficient and versatile alternative to polymer coatings.
- Tailoring lipid excipient selection based on physico-chemical properties is crucial for controlling drug release.
- This approach facilitates advanced drug delivery system development.
