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Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol

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Fat emulsions as diffusive reference standards for tissue simulating phantoms?

Paola Di Ninni¹, Yves Bérubé-Lauzière, Luca Mercatelli

¹Dipartimento di Fisica e Astronomia dell'Università degli Studi di Firenze, Firenze, Italy.

|October 24, 2012

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Fat emulsions like Intralipid, Lipovenoes, and Lipofundin S exhibit stable diffusive optical properties, making them suitable for tissue simulating phantoms. Their optical characteristics can be predicted based on composition, aiding in phantom development.

Area of Science:

Biomedical Optics
Optical Phantoms
Tissue Simulation

Background:

Intralipid 20% is a standard for diffusive optical properties in tissue phantoms.
Evaluating other fat emulsions is crucial for expanding phantom development.
Understanding optical properties is key for accurate light-tissue interaction studies.

Purpose of the Study:

To assess the diffusive optical properties of various fat emulsions.
To determine the suitability of Intralipid, Lipovenoes, and Lipofundin S as reference standards.
To investigate the relationship between fat emulsion composition and optical properties.

Main Methods:

Optical properties (absorption and reduced scattering coefficients) were measured at 751 nm.
Multiple fat emulsions (Intralipid, Lipovenoes, Lipofundin S) at different concentrations were analyzed.

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Batch-to-batch variations and scaling properties were evaluated.

Main Results:

All tested fat emulsions demonstrated high stability and low batch-to-batch variations.
Absorption coefficients were similar across Intralipid, Lipovenoes, and Lipofundin S.
Reduced scattering coefficients of 20% emulsions were similar (within 5%), and 10% and 30% emulsions showed predictable scaling properties.

Conclusions:

Intralipid, Lipovenoes, and Lipofundin S are suitable diffusive reference standards for tissue simulating phantoms.
The optical properties of these fat emulsions are predictable based on their composition.
These findings support the development of more accurate and versatile optical phantoms.