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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Allergic Reactions02:06

Allergic Reactions

Overview
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

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Transgenerational effects of bisphenol S exposure on the development of experimental asthma.

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Environmental estrogen exposures alter molecular signaling in immune cells that promote the development of childhood asthma.

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Related Experiment Video

Updated: May 17, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

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Published on: September 22, 2023

Estrogen effects in allergy and asthma.

Rana S Bonds1, Terumi Midoro-Horiuti

  • 1Division of Allergy/Immunology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555, USA. rsbonds@utmb.edu

Current Opinion in Allergy and Clinical Immunology
|October 24, 2012
PubMed
Summary

Estrogen significantly impacts allergic diseases, particularly asthma, in women. Research shows both natural and environmental estrogens (xenoestrogens) can worsen allergic responses and asthma development.

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Area of Science:

  • Immunology
  • Endocrinology
  • Environmental Health

Background:

  • Asthma and allergic diseases disproportionately affect women, with female sex hormones implicated.
  • Estrogen, a key female hormone, has been extensively studied for its role in immune responses.

Purpose of the Study:

  • To review recent research on the effects of estrogen in allergic diseases, focusing on asthma.
  • To explore the mechanisms by which estrogen influences allergic inflammation and lung function.

Main Methods:

  • Review of current scientific literature on estrogen and allergic disease.
  • Analysis of studies investigating estrogen receptors on immune cells.
  • Examination of pathways modulated by estrogen, including SLPI, TRPV1, and nitric oxide.

Main Results:

  • Estrogen receptors are present on immunoregulatory cells, and estrogen skews immune responses toward allergy.
  • Estrogen can directly and indirectly affect asthma by modulating inflammation and lung mechanics.
  • Environmental estrogens (xenoestrogens) like BPA and phthalates enhance allergic sensitization in animal models and may contribute to human atopic disorders.

Conclusions:

  • Estrogen's role in allergic disease is complex and warrants further investigation.
  • Understanding estrogen's effects is crucial given the increasing prevalence of allergic diseases in women.
  • Xenoestrogens represent a significant area of concern regarding their impact on allergic disease development.