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Related Experiment Video

Updated: May 17, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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Published on: April 2, 2012

Neonatal herpes simplex virus infection.

Thomas L Cherpes1, Dean B Matthews, Samantha A Maryak

  • 1Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. cherpestl@upmc.edu

Clinical Obstetrics and Gynecology
|October 24, 2012
PubMed
Summary

Neonatal herpes simplex virus (HSV) infection, a serious complication of pregnancy, can lead to infant disabilities despite treatment. Prevention strategies must target maternal infection near delivery and identify infants needing antiviral therapy.

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Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
11:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

Area of Science:

  • Neonatal infections
  • Virology
  • Maternal-fetal medicine

Background:

  • Neonatal herpes simplex virus (HSV) infection affects approximately 1 in 3000 live births in the US.
  • It is the most severe form of HSV infection during the perinatal period.
  • While acyclovir therapy reduces mortality, neurological disabilities remain common in affected infants.

Purpose of the Study:

  • To highlight the significance of neonatal herpes.
  • To emphasize the limitations of current treatments regarding long-term infant outcomes.
  • To underscore the need for improved prevention strategies for perinatal HSV transmission.

Main Methods:

  • Review of existing literature on neonatal herpes.
  • Analysis of transmission dynamics of HSV from mother to neonate.
  • Evaluation of current therapeutic and prophylactic approaches.

Main Results:

  • Mother-to-neonate HSV transmission is most efficient when maternal infection is acquired close to delivery.
  • Current antiviral therapies reduce infant mortality but do not eliminate neurological sequelae.
  • Identifying infants who would benefit from prophylactic antiviral therapy is crucial.

Conclusions:

  • Neonatal herpes prevention requires a dual approach: reducing maternal HSV acquisition during pregnancy and optimizing prophylactic therapy for at-risk infants.
  • Further research is needed to refine identification of high-risk infants for targeted antiviral prophylaxis.
  • Focusing on primary prevention of maternal HSV infection is key to reducing the burden of neonatal herpes.