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Updated: May 17, 2026
12:23
Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
Published on: April 24, 2020
Osteoarthritis, inflammation and obesity
Francis Berenbaum1, Florent Eymard, Xavier Houard
1University Pierre and Marie Curie, Paris VI, Sorbonne Universités, Paris, France. francis.berenbaum@sat.aphp.fr
Current Opinion in Rheumatology
|October 24, 2012
Summary
Obesity is linked to osteoarthritis, with adipokines from fat tissue playing a key role. Targeting these adipokines may offer new hope for osteoarthritis patients, particularly those with metabolic syndrome.
Area of Science:
- Biomedical science
- Immunology
- Metabolic disease research
Background:
- Obesity is a primary risk factor for knee osteoarthritis.
- Emerging data links obesity to hand osteoarthritis, suggesting systemic inflammatory mediators like adipokines are involved.
- Adipokines, released by adipose tissue, are implicated in osteoarthritis pathogenesis.
Purpose of the Study:
- To review the role of adipokines in osteoarthritis.
- To explore the link between obesity, adipokines, and osteoarthritis severity.
- To assess the therapeutic potential of targeting adipokines in osteoarthritis.
Main Methods:
- Review of recent experimental and epidemiological studies.
- Analysis of animal models of diet-induced obesity.
- Investigation into the role of specific adipokines, such as chemerin.
Main Results:
- Adipokines, including chemerin, are confirmed to play critical roles in osteoarthritis pathophysiology.
- Mechanical overload alone does not fully explain osteoarthritis aggravation in obese animal models.
- Certain adipokines may serve as biomarkers for osteoarthritis severity.
Conclusions:
- Preclinical research targeting adipokines shows promise for osteoarthritis treatment.
- Adipokine-targeted therapies could benefit osteoarthritis patients, especially those with metabolic syndrome.
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