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The DNAJA2 substrate release mechanism is essential for chaperone-mediated folding

Imad Baaklini1, Michael J H Wong, Christine Hantouche

  • 1Department of Biochemistry, McGill University and Groupe de Recherche Axé sur la Structure des Protéines, Montreal, Quebec H3G 0B1, Canada.

The Journal of Biological Chemistry
|October 24, 2012
PubMed
Summary

DNAJA1 and DNAJA2 are crucial co-chaperones for Hsp70/Hsc70. Specific domains within DNAJA2 are essential for substrate release and cellular functions, highlighting distinct mechanisms in protein folding.

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