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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Outcomes after thrombolysis in AIS according to prior statin use: a registry and review

Elena Meseguer1, Mikael Mazighi, Bertrand Lapergue

  • 1Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France. elena.meseguer@bch.aphp.fr

Neurology
|October 24, 2012
PubMed

Insights

Prior statin use in acute stroke patients undergoing thrombolysis showed no clear benefit or harm. Further research is needed for intra-arterial thrombolysis due to small sample sizes.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • The effect of pre-stroke statin medication on outcomes following thrombolytic therapy remains uncertain.
  • This study investigates the impact of prior statin use on patients receiving intravenous (IV), intra-arterial (IA), or combined thrombolysis for acute stroke.

Purpose of the Study:

  • To evaluate the association between prior statin use and clinical outcomes in acute stroke patients treated with different thrombolysis methods.
  • To synthesize evidence from a patient registry and systematic review to clarify the role of statins in thrombolysis.

Main Methods:

  • Analysis of a patient registry comprising 606 individuals.
  • Systematic review and meta-analysis of 11 existing studies involving 6,438 patients.

Main Results:

  • Statin users generally presented with more risk factors and concomitant antiplatelet use.
  • Prior statin use was not significantly linked to favorable outcomes or recanalization across treatment strategies.
  • Meta-analysis indicated no association with favorable outcomes, but a potential increase in symptomatic intracranial hemorrhage (sICH) risk, which became non-significant when multivariable data were combined.

Conclusions:

  • Prior statin use does not appear to confer a beneficial or detrimental effect in acute stroke patients treated with IV, IA, or combined thrombolysis.
  • The small number of patients undergoing IA or combined thrombolysis limits definitive conclusions regarding statin's impact in these specific groups.
Abstract

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