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Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

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Ivermectin residues in squab.

D C Bennett1, K M Cheng

  • 1University of British Columbia, Vancouver, British Columbia, V6T 1Z4 Canada. darin.bennett@ubc.ca

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|October 24, 2012
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Ivermectin transfers from parent pigeons to squabs, exceeding livestock limits initially. However, ivermectin residues rapidly deplete from squab tissues within one week, ensuring meat safety.

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Area of Science:

  • Veterinary Pharmacology
  • Animal Science

Background:

  • No approved drugs exist for nematode treatment in pigeons.
  • Ivermectin, an endectocide, is used off-label for pigeon parasite control.
  • Current withdrawal periods for squab are based on producer recommendations, not scientific data.

Purpose of the Study:

  • To investigate the depletion rate of ivermectin transferred from parent pigeons to their squabs.
  • To determine if ivermectin residues in squab meat comply with safety standards.

Main Methods:

  • Adult pigeons were administered ivermectin in drinking water for three days.
  • Ivermectin concentrations in squab breast meat and liver were measured post-treatment.
  • Tissue samples were analyzed at one week after parent treatment.

Main Results:

  • Ivermectin was transferred from treated parent pigeons to their squabs.
  • Initial ivermectin levels in squab tissues exceeded maximum residue limits for livestock.
  • Ivermectin was undetectable in squab tissues one week after parent treatment.

Conclusions:

  • Ivermectin transfer from parents to squabs occurs.
  • Squab tissues show a rapid decline in ivermectin levels within one week.
  • These findings suggest a short withdrawal period may be sufficient for ivermectin use in pigeons.