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Related Concept Videos

Translation01:31

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are called the...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
Termination of Translation01:44

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...

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Related Experiment Video

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Analysis of Translation Initiation During Stress Conditions by Polysome Profiling
10:59

Analysis of Translation Initiation During Stress Conditions by Polysome Profiling

Published on: May 19, 2014

Rustless translation.

Karl-Peter Hopfner1

  • 1Department of Biochemistry, Gene Center, Ludwig Maximilians University of Munich, Feodor-Lynen-Str. 25, D-81377 Munich, Germany. Hopfner@genzentrum.lmu.de

Biological Chemistry
|October 24, 2012
PubMed
Summary
This summary is machine-generated.

The ATP binding cassette E1 (ABCE1) protein, a conserved molecular machine, is identified as the ribosome-recycling factor. Its iron-sulfur clusters are crucial for protein synthesis by facilitating ribosome recycling in eukaryotes and archaea.

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Last Updated: May 17, 2026

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • ATP binding cassette (ABC) proteins are diverse molecular machines with various functions.
  • The specific role of ABCE1, the sole member of ABC subfamily E, was unknown for over a decade.
  • ABCE1 is highly conserved across eukaryotes and archaea, suggesting a fundamental biological role.

Purpose of the Study:

  • To elucidate the mysterious function of the ABCE1 protein.
  • To understand the role of ABCE1 in the context of protein synthesis.
  • To investigate the involvement of ABCE1's unique iron-sulfur clusters in its function.

Main Methods:

  • The study likely involved biochemical assays to test protein function.
  • Investigated the interaction of ABCE1 with ribosomal components.
  • Characterized the role of iron-sulfur clusters in ABCE1 activity.

Main Results:

  • ABCE1 has been identified as the ribosome-recycling factor in eukaryotes and archaea.
  • The two iron-sulfur clusters present in ABCE1 are essential for its function.
  • ABCE1 plays a critical role in the translational cycle by recycling ribosomes.

Conclusions:

  • ABCE1 is a key component of the protein synthesis machinery.
  • The ribosome-recycling activity of ABCE1 is conserved in eukaryotes and archaea.
  • Iron-sulfur clusters are integral to the catalytic mechanism of ABCE1 in ribosome recycling.