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[Vascular remodeling indicators and their impact on prognosis in patients with chronic heart failure]

N A Kosheleva, A P Rebrov

    Terapevticheskii Arkhiv
    |October 24, 2012
    PubMed

    Insights

    Aortic pulse wave velocity (APWV) is an independent risk factor for cardiovascular events in chronic heart failure (CHF) patients. Higher APWV indicates increased risk, highlighting its prognostic value.

    Area of Science:

    • Cardiology
    • Vascular Biology
    • Clinical Research

    Context:

    • Chronic heart failure (CHF) is associated with significant vascular dysfunction.
    • Vascular remodeling indicators are crucial for understanding CHF prognosis.
    • Assessing arterial stiffness and vasodilation provides insights into cardiovascular risk.

    Purpose:

    • To evaluate vascular remodeling markers in patients with chronic heart failure (CHF).
    • To determine the prognostic impact of these vascular indicators on cardiovascular events (CVE).
    • To investigate the relationship between arterial stiffness and vasodilation in CHF.

    Summary:

    • Patients with CHF exhibited reduced endothelium-dependent and -independent vasodilation (EDV and EIDV), increased carotid artery intima-media thickness (CA IMT), and abnormal arterial rigidity compared to controls.
    • EDV and EIDV correlated with CA IMT and aortic pulse wave velocity (APWV).
    • Elevated APWV (> 12 m/sec) was independently associated with a 2.02-fold increased risk of CVE in CHF patients within one year.

    Impact:

    • Aortic pulse wave velocity (APWV) is identified as an independent risk factor for cardiovascular events in CHF.
    • These findings highlight APWV as a valuable prognostic marker for risk stratification in heart failure patients.
    • The study underscores the importance of assessing arterial stiffness for managing cardiovascular risk in CHF.
    Abstract

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