[Radionuclide evaluation of renal function in essential hypertensive patients with chronic kidney disease]

Area of Science:

• Nephrology
• Nuclear Medicine
• Cardiology

Background:

• Arterial hypertension (AH) and chronic kidney disease (CKD) are significant comorbidities.
• Assessing renal function in AH patients with CKD is crucial for management.
• Radionuclide imaging offers a non-invasive method for evaluating kidney function.

Purpose of the Study:

• To evaluate renal function using radionuclide methods in patients with arterial hypertension and chronic kidney disease.
• To compare renal function in patients with AH and CKD versus CKD patients without AH.
• To investigate the relationship between glomerular filtration rate (GFR) and renal secretory/excretory function.

Main Methods:

• Dynamic nephroscintigraphy was performed on 31 patients with AH and CKD.
• A control group of 8 CKD patients without AH was included.
• Scintigraphic data were analyzed to assess renal secretory and excretory phases.

Main Results:

• Statistically significant differences in renal secretory and excretory functions were observed in AH patients with CKD.
• A deceleration in the secretory phase was noted when GFR was 30-59 ml/min.
• An acceleration in secretory function, indicated by a 3-fold reduction in peak radio tracer concentration, occurred when GFR was below 30 ml/min (p < 0.001).

Conclusions:

• Dynamic nephroscintigraphy effectively detects early renal secretory and excretory dysfunctions.
• The technique provides prognostic value in assessing the severity of renal dysfunction.
• Early identification of these dysfunctions necessitates timely pharmacological intervention.