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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
External Female Genitals01:15

External Female Genitals

The vulva encompasses the external structures of the female reproductive system. At the forefront is the monpubis, a cushion of fatty tissue atop the pubic bone. Once puberty sets in, this area typically grows hair. Extending from just behind the mons pubis are the labia majora (labia = 'lips'; majora = 'larger'), which are larger skin fs olds coated with hair. Nestled within are the labia minora (labia = 'lips'; minora = 'smaller'), which are thinner, more pigmented, and hairless. While the...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Videos

An apparently benign vulvar mass: possibly a rare malignancy.

E M Messalli1, M L D'Aponte, R Luise

  • 1Department of Gynaecology, Obstetrics and Reproductive Sciences, Second University of Naples, Naples, Italy. enricom.messalli@unina2.it

European Journal of Gynaecological Oncology
|October 25, 2012
PubMed
Summary

A rare vulvar dermatofibrosarcoma was diagnosed after a 16-year history of an apparently benign vulvar mass. Complete pathological examination is crucial for accurate diagnosis and to prevent recurrence.

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Area of Science:

  • Oncology
  • Dermatopathology
  • Surgical Pathology

Background:

  • Vulvar dermatofibrosarcoma is a rare, intermediate-grade malignant fibrous tumor.
  • It has a propensity for local recurrence and rare metastasis.
  • Multidisciplinary management is recommended.

Observation:

  • A 42-year-old woman presented with a 16-year history of an asymptomatic vulvar mass.
  • Previous gynecological procedures and hysterectomy did not resolve the lesion.
  • The mass evolved, showing erythematous skin with a "peau d'orange" appearance.

Findings:

  • Initial diagnosis was a benign vulvar mass.
  • Histopathological examination revealed positive margins after wide excision.
  • Subsequent deeper excision confirmed dermatofibrosarcoma, strongly CD34 positive.

Implications:

  • Complete pathological examination of vulvar lesions is essential, even if they appear benign.
  • Accurate diagnosis by pathologists is critical to ensure negative microscopic margins.
  • Preventing local recurrence requires thorough surgical and pathological assessment.