Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of primary human endometrial stromal cells on epithelial cell receptivity and protein expression is dependent on menstrual cycle stage.

Human reproduction (Oxford, England)·2010
Same author

Non-Gaussian space-variant resolution modelling for list-mode reconstruction.

Physics in medicine and biology·2010
Same author

Autoradiographic localization of cholecystokinin binding sites in human cerebellar system using a [(125)I]CCK8 probe.

Neurochemistry international·2010
Same author

Similar effect of caerulein on intracranial self-stimulation in vagotomized and non-vagotomized rats.

Neurochemistry international·2010
Same author

Changes in neurohypophysial cholecystokinin content during oestrous cycle in the rat.

Neurochemistry international·2010
Same author

A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker.

Diabetologia·2010

Related Experiment Video

Updated: May 17, 2026

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
12:01

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

[Positron emission tomography in inflammatory disorders].

S Goldman1

  • 1Service de Médecine nucléaire et Unité TEP/Cyclotron Biomédical, Hôpital Erasme, Bruxelles. sgoldman@ulb.ac.be

Revue Medicale De Bruxelles
|October 25, 2012
PubMed
Summary

Fluorodeoxyglucose-positron emission tomography (FDG-PET) offers significant advantages for evaluating inflammatory disorders. This whole-body imaging technique aids in diagnosing infectious, non-infectious inflammatory, and malignant diseases, especially for fever of unknown origin.

More Related Videos

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
09:41

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography

Published on: January 20, 2023

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)
10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Published on: May 2, 2012

Related Experiment Videos

Last Updated: May 17, 2026

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
12:01

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
09:41

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography

Published on: January 20, 2023

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)
10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

Published on: May 2, 2012

Area of Science:

  • Nuclear Medicine
  • Radiology
  • Immunology

Background:

  • Positron emission tomography (PET) is increasingly valued for metabolic evaluation of inflammatory disorders.
  • Fluorodeoxyglucose-PET (FDG-PET) has largely replaced Gallium-67 citrate, offering superior diagnostic capabilities.
  • Understanding tracer uptake requires considering immune cell activation, not just presence.

Purpose of the Study:

  • To highlight the advantages of FDG-PET in diagnosing inflammatory and infectious diseases.
  • To emphasize FDG-PET's role in the etiological diagnosis of fever of unknown origin.
  • To discuss the utility of FDG-PET in managing specific conditions like large vessel arteritis and inflammatory bowel disease.

Main Methods:

  • Utilizing FDG-PET for whole-body evaluation of systemic inflammatory disorders.
  • Combining FDG-PET with X-ray computed tomography (CT) for enhanced diagnosis of chronic infections.
  • Assessing tracer uptake to differentiate between infectious, inflammatory, and malignant processes.

Main Results:

  • FDG-PET effectively diagnoses chronic infectious diseases such as osteomyelitis and prosthesis infections.
  • The technique is valuable for systemic infections like tuberculosis.
  • FDG-PET aids in diagnosing and managing non-infectious inflammatory conditions, including large vessel arteritis and inflammatory bowel disease.

Conclusions:

  • FDG-PET is a powerful tool for the comprehensive evaluation of inflammatory and infectious diseases.
  • Its ability to detect both inflammatory and malignant conditions makes it crucial for undiagnosed fevers.
  • FDG-PET, especially when combined with CT, improves diagnostic accuracy for challenging clinical cases.