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Related Concept Videos

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Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
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Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Endocarditis I: Introduction01:25

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Related Experiment Video

Updated: May 17, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Acquired C1-inhibitor deficiency: a case report.

E Galdi1, L G Cremonte

  • 1SOS Dipartimentale di Allergologia ASL AL, Novi Ligure (AL), Italy.

European Annals of Allergy and Clinical Immunology
|October 25, 2012
PubMed
Summary

Acquired angioedema (AAE), a rare condition often linked to lymphoproliferative disorders, can be life-threatening if misdiagnosed. Early recognition in adults with angioedema is crucial for timely and effective treatment.

Area of Science:

  • Immunology
  • Hematology

Background:

  • C1-inhibitor deficiency can manifest as hereditary angioedema (HAE) or acquired angioedema (AAE).
  • Acquired angioedema (AAE) is rare, potentially underdiagnosed, and typically presents after age 40, often associated with lymphoproliferative disorders.

Observation:

  • A 74-year-old woman experienced recurrent upper airway angioedema episodes with a delayed diagnosis.
  • A concurrent diagnosis of B cell leukemia was made in the patient.

Findings:

  • Delayed diagnosis of AAE increases the risk of severe, life-threatening episodes.
  • AAE episodes in this case were unresponsive to standard angioedema therapies.

Implications:

  • Adult-onset angioedema warrants consideration of AAE as a differential diagnosis.

Related Experiment Videos

Last Updated: May 17, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

  • Thorough clinical history and evaluation of clinical features are essential for diagnosing AAE.
  • Prompt recognition and diagnosis of AAE are critical to prevent severe complications and ensure appropriate management.