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Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers

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Multifunctionalized microbubbles for cancer diagnosis and therapy.

Hao Li¹, Jianhao Wang, Gang Huang

¹School of Engineering, Sun Yat-Sen University, Guangzhou 510006, P. R. China.

Anti-Cancer Agents in Medicinal Chemistry

|October 25, 2012

Summary

Microbubbles (MBs) are tiny ultrasound-responsive particles that can carry drugs. Ultrasound triggers drug release and enhances imaging for targeted cancer diagnosis and therapy.

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Area of Science:

Biomedical Engineering
Nanotechnology
Medical Imaging

Background:

Microbubbles (MBs) are gas-filled microparticles with distinct acoustic properties.
Ultrasound interaction with MBs enhances echogenicity for improved imaging.
MBs can be engineered for targeted drug and gene delivery.

Purpose of the Study:

To review recent advancements in multifunctional microbubbles.
To highlight their potential in cancer diagnosis and therapy.
To discuss microbubble-mediated drug/gene delivery systems.

Main Methods:

Review of current literature on microbubble technology.
Analysis of ultrasound-triggered drug release mechanisms.
Evaluation of sonoporation effects for enhanced cellular uptake.

Main Results:

Multifunctionalized MBs show promise for targeted cancer treatment.
Ultrasound enables controlled drug release from MBs at specific sites.
Sonoporation facilitates increased intracellular delivery of therapeutic agents.

Conclusions:

Microbubbles represent a significant advancement in theranostic applications.
Multifunctional MBs offer a versatile platform for cancer diagnosis and therapy.
Further research into MBs can optimize drug/gene delivery for malignant tumors.