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Updated: May 17, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontitis and redox status: a review
1Periodontology Unit and Department of Clinical Research, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, UK. l.nibali@eastman.ucl.ac.uk
Current Pharmaceutical Design
|October 25, 2012
Summary
Reactive oxygen species contribute to periodontal disease by causing tissue damage. This review highlights increased oxidative stress in periodontitis and explores antioxidants as potential treatments.
Area of Science:
- Periodontal Medicine
- Oxidative Stress Research
- Biochemistry
Background:
- Periodontal diseases are inflammatory conditions leading to tooth loss.
- Reactive oxygen species (ROS) are implicated in periodontal tissue damage.
- Periodontitis is associated with systemic and local redox balance alterations.
Purpose of the Study:
- To review evidence on the role of ROS in periodontal tissue damage.
- To analyze methods for assessing oxidative stress in periodontitis.
- To discuss the relationship between oxidative stress and inflammation in periodontal disease.
Main Methods:
- Literature review of studies on oxidative stress and periodontitis.
- Appraisal of analytical methods for oxidative stress markers.
- Synthesis of evidence on redox balance in periodontitis.
Main Results:
- Increased oxidative stress markers and damage fingerprints are found in periodontitis.
- Evidence supports a role for ROS in periodontal tissue pathology.
- Alterations in redox balance are observed both locally and systemically.
Conclusions:
- Oxidative stress is a significant factor in the pathogenesis of periodontitis.
- Understanding redox status is crucial for periodontal medicine.
- Antioxidants may serve as adjunct therapies to mechanical treatments for periodontitis.
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