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Measuring nanoscale forces with living probes.

S N Olof1, J A Grieve, D B Phillips

  • 1H. H. Wills Physics Laboratory, School of Chemistry, University of Bristol, Bristol, BS8 1TL, United Kingdom.

Nano Letters
|October 25, 2012
PubMed
Summary

Living diatoms serve as advanced probes for holographic optical tweezing, offering advantages over traditional microspheres for biological research and force sensing applications.

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Area of Science:

  • Biophysics
  • Optical trapping
  • Cellular mechanics

Background:

  • Optical trapping commonly uses microspheres, limiting probe complexity.
  • Complex probe morphologies offer advantages like controlled interaction volumes and reduced photodamage.
  • Anisotropic probes enable multifunctional applications and asymmetric surface chemistry.

Purpose of the Study:

  • To explore the use of living diatom cells as advanced probes in holographic optical tweezing.
  • To characterize the optical and material properties of diatoms for tweezing applications.
  • To demonstrate diatoms as calibrated force sensors and probes.

Main Methods:

  • Holographic optical tweezing of Nitzschia subacicularis cells.
  • Characterization of diatom silica frustule's optical and material properties.

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  • Calibration of diatoms as force sensors in biological samples.

    • Main Results:

    • Demonstrated successful optical trapping of living diatom cells.
    • Quantified optical and material properties of the anisotropic diatom frustules.
    • Showcased diatoms' utility as calibrated force sensors and probes.

    Conclusions:

    • Living diatoms are viable and advantageous advanced probes for holographic optical tweezing.
    • Diatoms offer unique capabilities for studying biological processes and forces.
    • This approach expands the toolkit for advanced biophysical investigations.