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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Updated: May 17, 2026

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research
07:47

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

Circulating tumor cells: from bench to bedside.

Marija Balic1, Anthony Williams, Henry Lin

  • 1Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, 8036, Austria. marija.balic@medunigraz.at

Annual Review of Medicine
|October 25, 2012
PubMed
Summary
This summary is machine-generated.

Circulating tumor cells (CTCs) are increasingly vital biomarkers for detecting cancer spread and monitoring treatment effectiveness. Their real-time evaluation promises to enhance cancer patient management and guide novel therapeutic strategies.

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Area of Science:

  • Oncology
  • Biomarker Discovery
  • Translational Research

Background:

  • Circulating tumor cells (CTCs) are key indicators of hematogenous metastasis.
  • Detection and prognostic relevance of CTCs are well-established.
  • Growing interest in CTCs for predicting therapeutic response.

Purpose of the Study:

  • To review the clinical importance of CTCs in cancer management.
  • To highlight the role of CTCs in monitoring therapeutic response.
  • To discuss advancements in CTC detection and molecular characterization.

Main Methods:

  • Review of existing literature on CTC detection and clinical utility.
  • Analysis of translational studies on CTC molecular characterization.
  • Evaluation of CTCs as a monitoring parameter in clinical trials.

Main Results:

  • CTCs demonstrate significant prognostic and predictive value.
  • Clinical trials increasingly incorporate CTCs for monitoring.
  • Advancements in technology facilitate CTC molecular analysis.

Conclusions:

  • CTCs are poised for wider implementation as a diagnostic tool for real-time therapeutic response monitoring.
  • Novel technologies will enable further molecular characterization of CTCs.
  • Enhanced understanding of CTCs can lead to improved cancer treatment strategies.